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PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis. PDF available through Get Fulltext Research

Selvaraj, Vimal Soundarapandian, Mangala M Chechneva, Olga Williams, Ambrose J Sidorov, Maxim K Soulika, Athena M Pleasure, David E Deng, Wenbin

Published in The Journal of biological chemistry

Poly(ADP-ribose) polymerase-1 (PARP-1) has been implicated in the pathogenesis of several central nervous system (CNS) disorders. However, the role of PARP-1 in autoimmune CNS injury remains poorly understood. Therefore, we studied experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis in mice with a targeted deletion of PA...

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