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IFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis indep...

Lee, Eunyoung Chanamara, Sarah Pleasure, David Soulika, Athena M

Published in Journal of Neuroinflammation

BackgroundMurine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis, presents typically as ascending paralysis. However, in mice in which interferon-gamma (IFNγ) signaling is disrupted by genetic deletion, limb paralysis is accompanied by atypical deficits, including head tilt, postural imbalance, and circling, consiste...

Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune mul...

Mills Ko, Emily Ma, Joyce H Guo, Fuzheng Miers, Laird Lee, Eunyoung Bannerman, Peter Burns, Travis Ko, David Sohn, Jiho Soulika, Athena M ...

Published in Journal of Neuroinflammation

Multiple sclerosis (MS) is characterized by central nervous system (CNS) inflammation, demyelination, and axonal degeneration. CXCL10 (IP-10), a chemokine for CXCR3+ T cells, is known to regulate T cell differentiation and migration in the periphery, but effects of CXCL10 produced endogenously in the CNS on immune cell trafficking are unknown. We c...

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IFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis indep...

Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune mul...