IFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis indep...
Published in Journal of Neuroinflammation
BackgroundMurine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis, presents typically as ascending paralysis. However, in mice in which interferon-gamma (IFNγ) signaling is disrupted by genetic deletion, limb paralysis is accompanied by atypical deficits, including head tilt, postural imbalance, and circling, consiste...