Soulika Lab - UC Davis
  • Upload

  • Log in

  • Sign up

Search on MyScienceWork
News 30 Publications 4 Members

Studies of structure-activity relations of complement inhibitor compstatin.

Athena Soulika Morikis, D Sarrias, Mr Roy, M Spruce, La Sahu, A Lambris, Jd

Published in The Journal of Immunology

Compstatin, a 13-mer cyclic peptide, is a novel and promising inhibitor of the activation of the complement system. In our search for a more active analog and better understanding of structure-functions relations, we designed a phage-displayed random peptide library based on previous knowledge of structure activity relations, in which seven amino a...

Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to experimental autoi...

Burns, T Itoh, T Shen, H Lee, E Sohn, J Pleasure, D Guo, F Maeda, Y Ko, Em Delgado, M ...

Published in Journal of Neuroscience

Pharmacological studies have suggested that oligodendroglial NMDA glutamate receptors (NMDARs) mediate white matter injury in a variety of CNS diseases, including multiple sclerosis (MS). We tested this hypothesis in experimental autoimmune encephalomyelitis (EAE), a model of human MS, by timed conditional disruption of oligodendroglial NR1, an ess...

Characterization of the ATPase activity of human ATP-binding cassette transporter-2 (ABCA2).

Beljanski, V Athena Soulika Tucker, Jm Townsend, Dm Davis W, Jr Tew, Kd

Published in In Vivo

Complement activation by a B cell superantigen.

Kozlowski, Lm Athena Soulika Silverman, Gj Lambris, Jd Levinson, Ai

Published in The Journal of Immunology

Staphylococcal protein A (SpA), acting as a B cell superantigen, binds to the Fab region of human VH3+ Igs. Using SpA abrogated of its IgG Fc binding activity (Mod SpA) as a model B cell superantigen, we determined whether such an interaction causes complement activation. Addition of Mod SpA to human serum led to complement consumption and the gene...

"Skittish" Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous ...

Mack, Jt Beljanski, V Athena Soulika Townsend, Dm Brown, Cb Davis, W Tew, Kd

Published in Molecular and Cellular Biology

The ATP-binding cassette transporter 2 (ABCA2) is an endolysosomal protein most highly expressed in the central and peripheral nervous system tissues and macrophages. Previous studies indicated its role in cholesterol/steroid (estramustine, estradiol, and progesterone) trafficking/sequestration, oxidative stress response, and Alzheimer s disease. D...

Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE.

Moreno, M Guo, F Mills Ko, E Bannerman, P Athena Soulika Pleasure, D

Published in Journal of the Neurological Sciences

Astroglia, the most abundant cells in the human CNS, and even more prominent in multiple sclerosis patients, participate in CNS innate and adaptive immunity, and have been hypothesized to play an important role in multiple sclerosis progression. Experimental autoimmune encephalomyelitis elicited in mice by immunization with myelin oligodendrocyte g...

Inflammation in white matter: clinical and pathophysiological aspects.

Pleasure, D Athena Soulika Singh, Sk Gallo, V Bannerman, P

Published in Mental Retardation and Developmental Disabilities Research Reviews

While the central nervous system (CNS) is generally thought of as an immunopriviledged site, immune-mediated CNS white matter damage can occur in both the perinatal period and in adults, and can result in severe and persistent neurological deficits. Periventricular leukomalacia (PVL) is an inflammatory white matter disease of premature infants that...

Conditional ablation of astroglial CCL2 suppresses CNS accumulation of M1 macrophages and preserves axons in mice with M...

Moreno, M Bannerman, P Ma, J Guo, F Miers, L Athena Soulika Pleasure, D

Published in Journal of Neuroscience

Current multiple sclerosis (MS) therapies only partially prevent chronically worsening neurological deficits, which are largely attributable to progressive loss of CNS axons. Prior studies of experimental autoimmune encephalomyelitis (EAE) induced in C57BL/6 mice by immunization with myelin oligodendrocyte glycoprotein peptide 35-55 (MOG peptide), ...

Interaction of vaccinia virus complement control protein with human complement proteins: factor I-mediated degradation o...

Sahu, A Isaacs, Sn Athena Soulika Lambris, Jd

Published in The Journal of Immunology

Vaccinia virus complement control protein (VCP) is a virulence determinant of vaccinia virus that helps protect the virus from the complement attack of the host. To characterize the interaction of VCP with C3 and C4 and understand the mechanism by which VCP inactivates complement, we have expressed VCP in a yeast expression system and compared the ...

  • ← Previous
  • 1
  • 2
  • 3 (current)
  • Next →
Powered by Polaris
  • About this Platform
  • FAQ