Soulika Lab - UC Davis
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News 30 Publications 4 Members

Interferon-gamma inhibits healing post scald burn injury.

Shen, H Pamela Yao Lee, E Greenhalgh, D Athena Soulika

Published in Wound Repair and Regeneration

Impaired healing after severe burns remains a reason for prolonged hospitalization, opportunistic infections, and debilitating scarring. Interferon-gamma (IFN-γ) is an important immune regulator that has been shown to inhibit collagen synthesis by fibroblasts, resulting in delayed healing in incision wounds. To determine whether IFN-γ plays similar...

Binding kinetics, structure-activity relationship, and biotransformation of the complement inhibitor compstatin.

Sahu, A Athena Soulika Morikis, D Spruce, L Moore, Wt Lambris, Jd

Published in The Journal of Immunology

We have previously identified a 13-residue cyclic peptide, Compstatin, that binds to complement component C3 and inhibits complement activation. Herein, we describe the binding kinetics, structure-activity relationship, and biotransformation of Compstatin. Biomolecular interaction analysis using surface-plasmon resonance showed that Compstatin boun...

Compstatin inhibits complement activation by binding to the beta-chain of complement factor 3.

Athena Soulika Holland, Mc Sfyroera, G Sahu, A Lambris, Jd

Published in Molecular Immunology

Compstatin is a peptidic complement inhibitor that prevents the cleavage of complement factor 3 (C3) by C3 convertase. Compstatin differs from other C3-regulatory proteins, such as complement receptor (CR) 1 and decay-accelerating factor (DAF), in that it binds native as well as activated C3 fragments and acts through mechanisms that do not involve...

Improvement of the anti-C3 activity of compstatin using rational and combinatorial approaches.

Morikis, D Athena Soulika Mallik, B Klepeis, Jl Floudas, Ca Lambris, Jd

Published in Biochemical Society Transactions

Compstatin is a 13-residue cyclic peptide that has the ability to inhibit the cleavage of C3 to C3a and C3b. The effects of targeting C3 cleavage are threefold, and result in hindrance of: (i) the generation of the pro-inflammatory peptide C3a, (ii) the generation of opsonin C3b (or its fragment C3d), and (iii) further complement activation of the ...

Association of ABCA2 expression with determinants of Alzheimer s disease.

Chen, Zj Vulevic, B Ile, Ke Athena Soulika Davis W, Jr Reiner, Pb Connop, Bp Nathwani, P Trojanowski, Jq Tew, Kd ...

Published in The FASEB Journal

With the use of a novel method for detecting differential gene expression, alterations in functional gene clusters related to transport or oxidative stress response and beta-amyloid (Abeta) peptide metabolism were identified in a HEK293 cell line engineered to overexpress the human ATP binding cassette transporter ABCA2. These included fatty acid b...

Inhibition of heparin/protamine complex-induced complement activation by Compstatin in baboons.

Athena Soulika Khan, Mm Hattori, T Bowen, Fw Richardson, Ba Hack, Ce Sahu, A Edmunds Lh, Jr Lambris, Jd

Published in Clinical Immunology

Complement activation products are major components of the inflammatory response induced by cardiac surgery and cardiopulmonary bypass which contribute to postoperative organ dysfunction, fluid accumulation, and morbidity. Activation of the complement system occurs during extracorporeal circulation, during reperfusion of ischemic tissue, and after ...

Glutathione and ABC transporters as determinants of sensitivity to oxidative and nitrosative stress.

Tew, Kd Boyd, Jt Chen, Zj Davis W, Jr Fazilev, F Findlay, V Gaté, L Ile, K Athena Soulika Townsend, Dm ...

Published in Journal of Nutrition

Identification of a novel first exon of the human ABCA2 transporter gene encoding a unique N-terminus.

Ile, Ke Davis W, Jr Boyd, Jt Athena Soulika Tew, Kd

Published in Biochimica et Biophysica Acta

The human ABCA2 transporter is a member of a large family of ATP-binding proteins that transport a variety of molecules across biological membranes. Using RNA ligation-mediated PCR (RLM-PCR), we have identified a novel first exon, which we designate 1B that is located 699 bp upstream of the previously characterized first exon, which we designate 1A...

Herpes simplex virus type 1 glycoprotein gC mediates immune evasion in vivo.

Lubinski, Jm Wang, L Athena Soulika Burger, R Wetsel, Ra Colten, H Cohen, Gh Eisenberg, Rj Lambris, Jd Friedman, Hm ...

Published in Journal of Virology

Many microorganisms encode proteins that interact with molecules involved in host immunity; however, few of these molecules have been proven to promote immune evasion in vivo. Herpes simplex virus type 1 (HSV-1) glycoprotein C (gC) binds complement component C3 and inhibits complement-mediated virus neutralization and lysis of infected cells in vit...

Astrogliosis in EAE spinal cord: derivation from radial glia, and relationships to oligodendroglia.

Bannerman, P Hahn, A Athena Soulika Gallo, V Pleasure, D

Published in Glia

A prominent feature of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) is the accumulation of enlarged, multipolar glial fibrillary acidic protein (GFAP) and brain lipid binding protein (BLBP) immunoreactive astroglia within and at the margins of the inflammatory demyelinative lesions. Whether this astrogliosis is due to...

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