Soulika Lab - UC Davis
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News 30 Publications 4 Members

Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodyni...

Sa, Woller Sb, Ravula Fc, Tucci G, Beaton M, Corr Rr, Isseroff Athena Soulika M, Chigbrow Ka, Eddinger Tl, Yaksh ...

Published in Brain Behavior and Immunity

Objective: Pain resulting from local tissue injury or inflammation typically resolves with time. Frequently, however, this pain may unexpectedly persist, becoming a pathological chronic state. Increasingly, the innate and adaptive immune systems are being implicated in the initiation and maintenance of these persistent conditions. In particular, To...

Out-of-Sequence Signal 3 Paralyzes Primary CD4(+) T-Cell-Dependent Immunity. PDF available through Get Fulltext Research

Sckisel, Gail D Bouchlaka, Myriam N Monjazeb, Arta M Crittenden, Marka Curti, Brendan D Wilkins, Danice E C Alderson, Kory A Sungur, Can M Ames, Erik Mirsoian, Annie ...

Published in Immunity

Primary T cell activation involves the integration of three distinct signals delivered in sequence: (1) antigen recognition, (2) costimulation, and (3) cytokine-mediated differentiation and expansion. Strong immunostimulatory events such as immunotherapy or infection induce profound cytokine release causing "bystander" T cell activation, thereby in...

Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune mul... PDF available through Get Fulltext Research

Mills Ko, Emily Ma, Joyce H Guo, Fuzheng Miers, Laird Lee, Eunyoung Bannerman, Peter Burns, Travis Ko, David Sohn, Jiho Soulika, Athena M ...

Published in Journal of Neuroinflammation

Multiple sclerosis (MS) is characterized by central nervous system (CNS) inflammation, demyelination, and axonal degeneration. CXCL10 (IP-10), a chemokine for CXCR3+ T cells, is known to regulate T cell differentiation and migration in the periphery, but effects of CXCL10 produced endogenously in the CNS on immune cell trafficking are unknown. We c...

Conditional ablation of astroglial CCL2 suppresses CNS accumulation of M1 macrophages and preserves axons in mice with M...

Moreno, Monica Bannerman, Peter Ma, Joyce Guo, Fuzheng Miers, Laird Soulika, Athena M Pleasure, David

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

Current multiple sclerosis (MS) therapies only partially prevent chronically worsening neurological deficits, which are largely attributable to progressive loss of CNS axons. Prior studies of experimental autoimmune encephalomyelitis (EAE) induced in C57BL/6 mice by immunization with myelin oligodendrocyte glycoprotein peptide 35-55 (MOG peptide), ...

Catecholamine stress alters neutrophil trafficking and impairs wound healing by β2-adrenergic receptor-mediated upregula... PDF available through Get Fulltext Research

Kim, Min-Ho Gorouhi, Farzam Ramirez, Sandra Granick, Jennifer L Byrne, Barbara A Soulika, Athena M Simon, Scott I Isseroff, Rivkah R

Published in The Journal of investigative dermatology

Stress-induced hormones can alter the inflammatory response to tissue injury; however, the precise mechanism by which epinephrine influences inflammatory response and wound healing is not well defined. Here we demonstrate that epinephrine alters the neutrophil (polymorphonuclear leukocyte (PMN))-dependent inflammatory response to a cutaneous wound....

IFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis indep... PDF available through Get Fulltext Research

Lee, Eunyoung Chanamara, Sarah Pleasure, David Soulika, Athena M

Published in Journal of Neuroinflammation

BackgroundMurine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis, presents typically as ascending paralysis. However, in mice in which interferon-gamma (IFNγ) signaling is disrupted by genetic deletion, limb paralysis is accompanied by atypical deficits, including head tilt, postural imbalance, and circling, consiste...

PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis. PDF available through Get Fulltext Research

Selvaraj, Vimal Soundarapandian, Mangala M Chechneva, Olga Williams, Ambrose J Sidorov, Maxim K Soulika, Athena M Pleasure, David E Deng, Wenbin

Published in The Journal of biological chemistry

Poly(ADP-ribose) polymerase-1 (PARP-1) has been implicated in the pathogenesis of several central nervous system (CNS) disorders. However, the role of PARP-1 in autoimmune CNS injury remains poorly understood. Therefore, we studied experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis in mice with a targeted deletion of PA...

Therapeutic depletion of monocyte-derived cells protects from long-term axonal loss in experimental autoimmune encephalo...

Moreno, Ma Burns, T Pamela Yao Miers, L Pleasure, D Athena Soulika

Published in Journal of Neuroimmunology

Studies in multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE) suggest that peripheral monocyte-derived cells (MDCs) are instrumental for disease initiation. MDCs, however, are plastic, and may exert various functions once in the central nervous system (CNS) for prolonged periods. Furthermore, the long-term effec...

Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis.

Athena Soulika Lee, E Mccauley, E Miers, L Bannerman, P Pleasure, D

Published in Journal of Neuroscience

Axonal loss is the principal cause of chronic disability in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). In C57BL/6 mice with EAE induced by immunization with myelin oligodendrocyte glycoprotein peptide 35-55, the first evidences of axonal damage in spinal cord were in acute subpial and perivascular foci of infiltrating n...

Oral administration of aflatoxin G₁ induces chronic alveolar inflammation associated with lung tumorigenesis.

Liu, C Shen, H Yi, L Shao, P Athena Soulika Meng, X Xing, L Yan, X Zhang, X

Published in Toxicology Letters

Our previous studies showed oral gavage of aflatoxin G₁ (AFG₁) induced lung adenocarcinoma in NIH mice. We recently found that a single intratracheal administration of AFG₁ caused chronic inflammatory changes in rat alveolar septum. Here, we examine whether oral gavage of AFG₁ induces chronic lung inflammation and how it contributes to carcinogenes...

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